Scientific References
Unlike ordinary hop extracts, pHix uses a unique, research-backed formulation designed specifically to promote healthier weight, better energy, and clearer thinking. And yes – it actually works.
Here’s the science that helps to demonstrate – these peer-reviewed studies relate to matured hop extract or its active compounds.
Helps Reduce Visceral Fat (Deep Belly Fat)
Matured hop extract supports reduction of visceral fat — the deep fat stored around your organs that is linked to metabolic health risks. It promotes fat loss by stimulating natural fat-burning processes in brown adipose tissue.
- Morimoto-Kobayashi et al., 2015. Matured hop bittering components induce thermogenesis in brown adipose tissue via sympathetic nerve activity. PLoS ONE. DOI:10.1371/journal.pone.0131042
- Morimoto-Kobayashi et al., 2015. Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled study. Nutr J. DOI:10.1186/s12937-016-0144-2
- Suzuki et al., 2018. Relationship between matured hop extract and physical activity on body fat reduction. Nutr J. DOI:10.1186/s12937-018-0405-3
Supports Stress and Anxiety Reduction
Compounds in matured hop extract may help reduce mild feelings of stress and anxiety by influencing brain pathways involved in mood regulation.
- Bolton et al., 2019. The Multiple Biological Targets of Hops and Bioactive Compounds. Chem Res Toxicol. DOI:10.1021/acs.chemrestox.8b00313
Enhances Cognitive Function and Mental Clarity
Research shows matured hop bitter acids support brain health by activating the vagus nerve and increasing neurotransmitters important for memory and learning, which helps improve cognitive function.
- Ayabe et al., 2018. Matured hop-derived bitter components improve hippocampus-dependent memory through activation of the vagus nerve. Sci Rep. DOI:10.1038/s41598-018-33866-1
- Fukuda et al., 2019. Matured hop bitter acids improve spatial working and object recognition memory via nicotinic acetylcholine receptors. Psychopharmacology. DOI:10.1007/s00213-019-05263-7
- Bolton et al., 2019. The Multiple Biological Targets of Hops and Bioactive Compounds. Chem Res Toxicol. [DOI above]
Anti-Inflammatory and Metabolic Benefits
Matured hop extract also has anti-inflammatory properties that may help reduce low-level inflammation linked to metabolic syndrome, supporting blood sugar regulation and cardiovascular health.
- Bolton et al., 2019. The Multiple Biological Targets of Hops and Bioactive Compounds. Chem Res Toxicol. [DOI above]
Metabolism and Appetite Control
Matured hop compounds can modulate gut hormones that regulate appetite and energy balance, helping to reduce overall energy intake and support metabolism.
- Walker et al., 2022. An extract of hops modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial. Am J Clin Nutr.
- Yamazaki et al., 2019. Secretion of gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue. J Nutr Biochem. DOI:10.1016/j.jnutbio.2018.10.009
Safety and Tolerability
Extensive genetic and toxicity studies confirm that matured hop extract is safe for use within recommended doses.
- Suzuki et al., 2018. Genetic, acute and subchronic toxicity studies of matured hop extract. J Toxicol Sci. DOI:10.2131/jts.43.473